What's behind the recent "Fractal Frenzy" in Personalized Medicine?


It is all about Geometry of Nature. Geos, the Universe, the Brain ... and the DNA.
Actually, it is at least a 2500 year long, steady story, with only the last 200 years accelerating. Even the last chapters only became "hurried" under extraordinary pressures; going for nuclear energy, computational ballistics, information geometry for intelligence, control of fighter jets by neural nets - or recently...Personalized Medicine

569 BC - 475 BC
Pythagoras.
Theorem of Pythagoras'
Greek "Geometer", Samos, Ionia
Distance measure in flat geometries (e.g. a surface) is x2 + y2 = d2
(Theorem of Pythagoras' - middle school today)

324 - 265 BC
Euclid (Elements).
Mathematical Language of Nature by Euclidean "Geo-Metry" is at least 2000 years old.
Measured land (flat 2-dimensional surfaces of Geos) in Egypt (Alexandria).

1596 - 1650
Descartes
associates Brain Function with internal representation in Euclidean Geometry

1642 - 11727
Isaac Newton
establishes physics and mechanics based on Euclidean Geometry

------------------ FIRST "BIFURCATION" - BREAKING AWAY FROM EUCLIDEAN GEOMETRIES -----------

1775-1856
Farkas Bolyai
and his son
1802-1860
János Bolyai and
1777-1855
Johann Gauss
collectively establish the hard mathematical core, that "Alternative Geometries" to Euclidean axioms are equally possible

------------------ SECOND "BIFURCATION" - NON-DIFFERENTIABLE GEOMETRIES APPEAR, -----------

1831-1889
duBois Reymond
blows open the field by proving continuous nondifferentiable function constructed by Weierstrass

1845-1918
Cantor
set theory - an early predecessor of self-similarity theories - a core notion to later "fractals"

------------------ THIRD "BIFURCATION" - CURVED GEOMETRY OF SPACETIME MANIFOLD TO SERVE PHYSICS OF UNIVERSE-----------

1864-1907
Minkowski
established that space and time form a 4-dimensional manifold with a unified geometry. Euclidean separable x,y,z and t are blown away

1879-1955
Albert Einstein
established that the metric tensor of the spacetime continuum is not uniform, the spacetime manifold is curved

------------------ FOURTH "BIFURCATION" - QUANTUM MECHANICS TAKES OFF TO SERVE NUCLEAR PHYSICS-----------

1901-1976
Heisenberg
1887-1961 Schrödinger
Establish quantum-mechanics, deviating from smooth-differentiable manifolds to generate the intrinsic mathematics for nuclear physics

1868-1942
Hausdorff
-dimension gave quantitative measure of non-integer dimension.

1875-1941
Lebesgue
contributes with the "Lebesgue measure"

1902-1950
Zipf
, with "Zipf's law" lays the rules of repetition

1955
Shannon
information theorist deciphers military encryption

1955
Johnny von Neumann
, done with von Neumann Algebra, declares that the intrinsic mathematics of brain function is unknown

------------------ FIFTH "BIFURCATION" - DISCOVERY OF DOUBLE HELIX IMPLIES THAT "HELIXO"-METRY WILL BE NECESSITATED, AS EUCLIDEAN "GEO"-METRY IS UNLIKELY TO SUFFICE FOR DNA-----------

1953
Francis Crick and James Watson
discover the extrinsic geometry of the Genome: the Double Helix. Have the book with all ACTG letters. What does it say? In what language? Where is the code-book? What is the encryption-algorithm? Francis Crick turns later to Neural Networks for some answers.

1977
Genentech, inc
. is incorporated in Greater Silicon Valley. Going for the "silver bullets" of medicine, just like starting to build a thermonuclear bomb before the physics is done. The pressure is "on".

1975-1977
Prof. Benoit Mandelbrot
coins "Fractals" and publishes the Classic Book: "The Fractal Mathematics of Nature". Suspects that brain cells are also fractals

------------------ SIXTH "BIFURCATION" - "FRACTAL FRENZY" IS SET OFF BY MANDELBROT - A HUGE FIELD OF FRACTAL GEOMETRY, FRACTAL ART AND FRACTAL DATA COMPRESSION EMERGES, SEE SKETCHY HISTORY

------------------ SEVENTH "BIFURCATION" - "FRACTAL FRENZY" IN PERSONALIZED MEDICINE - SEE SEPARATE "FRACTALS IN PERSONALIZED MEDICINE COLLECTION"