What is behind the "Fractal Frenzy" in Personalized Medicine?
It is all about Geometry of Nature. Geos, the Universe, the Brain ... and the DNA.
Actually, it is at least a 2500 year long, steady story, with only the last 200 years accelerating. The last chapter of half a Century became extremely "hurried" under extraordinary pressures; this time going for
Personalized Medicine
PRESENT
HelixoMetry, Inc, FractoGene (Patent Pending), Silicon Valley, USA (Dr. András Pellionisz)
The Hunt Laboratory, UC San Francisco, USA (Dr. Anthony Hunt)
Fractalgenomics, Inc., San Francisco, USA (Dr. Sandy Shaw)
Fractal EU Competence Centre, The Netherlands, West Europe (Dr. Jules Ruis)
Fractal EU Competence Centre, Hungary, Central Europe (Dr. Tamás Vicsek)
HISTORY
1953
Geo-Metry or Helixo-Metry?
Francis Crick and James Watson discover the extrinsic geometry of the Genome: the Double Helix. Have the book with all ACTG letters. What does it say? In what language? Where is the code-book? What is the encryption-algorithm? Francis Crick turns later to Neural Networks for some answers.
1977
Genentech, inc. is incorporated in Greater Silicon Valley by Bob Swanson and Jean Deleage. Going for the "silver bullets" of medicine, just like starting to build a thermonuclear bomb before the physics is done. The pressure was "on".
1975-1977
Fractal Geometry of Nature
Benoit Mandelbrot's classic. He coined the term "Fractal" and established "fractal art" with the "Mandelbrot-set". Suspected that brain cells are also fractals.
Boston University, Center for Polymer Studies
Biofractals collection Patterns in Nature
Nonlinear dynamics in life sciences
1980
Prof. Pellionisz' metric tensor defines the curved geometry of the geometrical function of brain (the Cerebellum). Tensor Network Theory spaces by means of Moore-Penrose generalized inverse. Sensorimotor theory of covariant and contravariant vectors stands experimental scrutiny by Gielen, Zuylen (Holland) and Peterson et al. (Chicago) - although understood by very few beyond a small circle, even today. Almost two decades later, connection between covariant vectors and fractals is conceptually established.
1985
Profs. Gielen and Zuylen in Holland and Peterson et al. in Chicago experimentally verify Pellionisz' Tensor Network Theory for Nature's geometry of brain function
1987
Prof. Walter Freeman (Berkeley) uses chaos theory to describe how brains make chaos to make sense of the world.
1989
Prof. Eckmiller (Bonn) nominates Pellionisz to win the "Distinguished Senior American Scientist" award (Humboldt Prize) by Germany for his Geometrical Approach to Brain Function.
1989
Pellionisz shows that Neuron (Purkinje cell) is fractal. Suspects that "self-similarity" will have to do with the Genome, as there can not be enough information in the genome for specifying each dendritic tree
1990
Pellionisz develops blueprint for "Decade of the Brain" for NIH-NIMH-NSF and "Flying with artificial cerebellar Neural Nets" for NASA Ames
1990
Pellionisz receives Alexander von Humboldt Prize for Senior Distinguished American Scientists, and spends half a year in Germany
1994
Mategna, et. al. suspect that Genetic Code has a language-like underpinning. The functional geometry is unknown. Zipf-law in DNA basepair-sequences is substantiated
1999
9 years after Pellionisz submits plan, NASA Ames-Dryden flies an F15 fighter plane with Neural Nets
Fractal dimension of proteins
http://www.mdpi.net/ecsoc-5/c0001/c0001.doc
1998
Erhard Bieberich: Connection made between Pellionisz' Tensor Network Theory of covariant and contravariant vectors and Fractals. Mathematical analysis 2. A covariant component of the input vector vi' is iteratively subtracted until the output vector vi is orthogonal to ui. This computational process is similar to a model introduced by Pellionisz and Llinas for signal adjustment of sensory input to executive motor output vectors in the cerebellum (Pellionisz A. and Llinas R., 1980). By this adjustment the system of u-vectors is consistent with the construction of the Sierpinski triangle by a tree like network with the enclosed angles determining the direction cosines (Fig. 2C). It should be noted for purpose of generalization that the network construction of the fractal is again directed by a linear affine transformation
2001
Human Genome Project is finished, DNA revealed, code is not, with up to 97% "Junk Genes"...
Jan 14. 2002
HelixoMetry incorporates with Pellionisz as founder, less than half a Century after Watson and Crick created the demand for Double Helix' intrinsic "Geo"- Metry
Feb. 16, 2002
FractoGene conceived, coined by Pellionisz and first offered in powerpoint 7th of March, 2002 March
May 15, 2002
HelixoMetry signs non-exclusive agreement with Translation Memory Company - not involving FractoGene
July 15, 2002
Pellionisz receives the "National Leadership Award" from Congress
Aug. 1, 2002
FractoGene Patent (pending) is electronically submitted to USPTO Aug. 1st, 2002 (hard copy acknowledgement received)
Sept. 2, 2002
Press Release on the Patent (Pending) of FractoGene, the Fractal Language of Genetic Code
Sept. 10, 2002
FractoGene Patent & Technology websites designate 7 marketing areas
Sept. 20, 2002
Websites spotted with compatible approaches: Bay Area
Sept. 21, 2002
Websites spotted with foundation of Network Science: Barabási Books
Sept. 22, 2002
Websites spotted with compatible approaches: Academic: Network Dynamics Research Group: Santa Fe
Sept. 22, 2002
Websites spotted with compatible efforts to uncover connections: Corporate
Sept. 25, 2002
Florida Investment Bank approaches HelixoMetry to finance FractoGene, Morgan Stanley approaches HelixoMetry for Investment Banker role
Sept 28, 2002
Pellionisz gets invitation to give plenary Lectures, and Publish Book
Sept 29, 2002
Pellionisz is interviewed about FractoGene by TV stations in New York / New Jersey / Connecticut / Florida / Hungary
Oct. 7, 2002
Pellionisz, founder of HelixoMetry & Inventor of FractoGene enters into term sheet discussions with Sophisticated Angels
Oct. 22, 2002
Prof. Anthony Hunt (UCSF, Hunt lab in top ten), in addition to continuing to feature as the "main picture" of the website a fractal interpretation of microarray data (by Hunt lab alumnus, Sandy Shaw), but now defines his lab by "Computational Therapeutics" and "Therapeutic Engineering".
Nov. 21, 2002
Massive News Media Response to FractoGene to evaluate its investment potential
Dec. 21, 2002
Massive News 4 "Big Pharma" Negotiations squeeze out Venture Capital involvement in financing FractoGene/Helixometry
